"Weapons being very samey" is the one that's got me stuck. 2e D&D and Street Fighter (shudder) have weapons have different initiative modifiers, which is kinda big in both systems, on top of different damage types and different amounts of damage. But I can't really think of any systems where it feels like a whole new game when you pick up a new weapon, the way 1st person shooter video games like Doom or Unreal Tournament have weapons that involve completely different gameplay.

Anybody got a pen & paper RPG where different weapons really feel different?