Off the top of my head:
Make a party of all strength based fighters. You will not be able to defeat the dragon unless you are playing on explorer mode. They'll also REALLY struggle against Kethric Thorm, I would expect an honor mode to struggle to enter act 3 with all strength based GWM PAM fighters. The magma elemental will also be unbelievably tough (in honor mode it creates its own magma, so you need someone who can cancel out its regen).
There are certain outcomes with Kagha that are virtually impossible to get without having a druid (preferably, a high intelligence one).
There's the spiders in the goblin camp, you can get a certain outcome if you can talk to them. Relying on potions is IMO not reliable, there are more animals to talk to than potions. In fact having speak with animals in BG3 makes a massive difference.
There's an outcome with Auntie Ethel that requires someone in the party is good at charisma checks and/or can boost ability checks.
I'm sure there is more, but I'm equally sure it's not worth the time and energy to find them for the sake of this thread. (also, yes I know about save scumming, and no I don't consider it valid, you'd never be able to save scum at table top)
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Aaaand this out of nowhere judgemental nonsense is exactly why I don't like posting anything about what happens in games on this board.
If the party is all spellcasters then yes I will ensure that there are fair consequences. No, I will not elaborate. Just assume nice things about me.
Of course I give them something. I always make sure to give many things. They could've literally climbed down and up the ravine, they had climbing gear. They were level 6. Some of them might have been able to JUMP across. One had misty step.
Am I supposed to railroad them? Into an obstacle?