...I'm not quite sure how to answer that, since I'm not quite sure what you mean. I don't see the playbooks working all that differently from how they work in a more typical superhero setting... although, the "Freak" label is going to be a bit more prominent, since most superheroes are strange, mysterious monstrosities by the standards of normal people, and the more esoteric your powers are, the more it's a battle to stop other people from seeing you as a freak. In that regard, the Transformed's only real disadvantage is that they can't pretend to be a normal person.
Otherwise, I think I'm mostly going to be dealing with the playbooks on a case-by-case basis, seeing what players come up with and working with how far they want to push the boundaries of their playbook.