Spider-Man vs The Red Goblin in Amazing Spider-Man 800.

To set the stage, in the climax of Superior Spider-Man, Norman Osborn was injected with nanomachines that suppress his powers and neutralize the goblin formula if he tried to inject more.

After trying numerous means of either getting his powers back, replacing them with some other powers, or trying to be a threat without power, he eventually decided to go for broke and stole the Carnage symbiote from Captativty and bonded with it. He made it purge the nanomachines from his body and then took another dose of the Goblin formula for good measure, which, since the Canarg symbiote was in his system when he took it, enhanced it as well, powering up all of its abilities, making it immune to fire, sonics, and electricity, and giving it the ability to breathe fire

During this storyline, called Go Down Swinging, soborn, now going by, well, Red Goblin, has run roughshod over Spider-Man and his allies, after having previously kidnapped J. Jonha. Jameson to learn what he knows about Spider-Man, with Jonah, who has since learned Peter's identity, accidentally spilling the beans when he quipped that not even "killing his girl" broke Spider-Man for long, causing Osborn to regain his memories of who PeterWas after he put to and two together with his memories of kidnapping and killing Gwen Stacy.

In the climax of the story, after Red Goblin has absolutely thrashed Miles, Silk, The Human Torch, Clash, Doc Ock(in his "Superior Octopus" clone body,) and a remote operated Spider-Slayer controlled by Jameson, as well as seriously wounding Anti-Venom and exhausting Venom and Mary Jane, who at this point in time was acting CEO of Stark Industries and had access to anti-symbiote security measures and a repulsor gauntlet, it's down to just Peter.

Before he taps out, Eddie Brock offers Peter the symbiote and, to show how desperate Peter is at this point, he accepts.

Eddie: "You behave yourself now."
Peter: "You heard him, suit."
Eddie: "I was talking to you."

so Peter, now empowered by the Venom Symbiote, goes off to confront the Red Goblin and... It's still not enough. Peter is losing, before the badly wounded Anti-Venom turns up. The Anti-Venom symbiote is literally melting off of Flash Thompson's body because he's stressed it to the limit healing The Red Goblin's victims... And reveals that he'd purged the traces of Carnage that Osborn had left behind in them in order to torture them to death later as a last screw you to Peter.

Osborn i so enraged by this that he mortally wounds Flash and...

Flash Thomspon is a very interesting character. He was introduced as a two-dimensional jock-bully in the high school years, but in college he and PEter reconciled, Flash became a better person, and he became ne of Peter's Best friends

He was also, as Agent Venom, the Venom Symbiote's favorite host. The only reason it went back to Eddie is because they were separated by force and Eddie was available when it couldn't find Flash, and it would have gone back to Flash if it could have but, you know, Anti-Venom.

so as Flash is lying on the ground, dying at Osborn's hands... For the first time, Peter and the Symbiote are in perfect synch. For one brief moment, there is no Spider-Man, and there is no symbiote... There is only Venom.

Peter-as-Venom then punches Th Red Goblin all the way across Manhattan, threw a building. They prepare to go off and finish Osborn off... But Flash uses the last of his strength to beg them not to become/regress back into a monster. Peter and the Symbiote calm down, and confront Osborn again, can't beat him even with the power-up from being in synch...

So Peter points out that if Ossborn kills him while wearing Carnage, credit for the kill is going to go to Cletus Kassady(who is dead at this point, IIRC, but we see a representation of him watching the fight from behind his symbiote's eyes.)

Playing Osborn like a fiddle, Peter proposes that they both renounce their symbiotes and finish this one-on-one. As Venom peals off of him, he wishes the symbiote luck in finding its way back to Eddie—and note that from this point forward, neither Peter nor the symbiote have any resentment for the other—and then manages to get the upper hand against Norman when he's merely the Green Goblin, as he always does.

Osborn suddenly realizes that the's been played and tries to call back Carnage to finish the fight, but Peter manages to destroy its main body just as it starts bonding, which ends the fight as Osborn goes catatonic from the feedback...

Then Jameson comes walking up with a pistol, trying to work up the nerve to kill Osborn citing how dangerous he is and how he knows Sider-Man's identity know, but Peter insists that Osborn is harmless right now and that killing him would be wrong. Jameson, however, is wracked with guilt for inadvertently exposing Peter's identity to Osborn and putting his friends and family at risk and takes his shot...

But Peter takes the bullet(in the arm) and when Jameson askes why, Peter simply replies "with great power comes great responsibility—to everyone."

Dan Slott's run on Spider-Man is controversial and for good reason, but his final storyline as the writer of Amazing Spider-Man, he got Peter exactly right.