Wandering Xykon is a Monster, not a player. He follows all the rules for Monsters except for those that relate to his movement and other unique capabilities.
That makes most of the next few answers obvious, but I'll go through them anyway:
No. Only players can trigger Explosive Runes.
No. Only players take damage from Explosive Runes.
Yes, because he is a Monster. Note that the part where the Monster is "saved as normal" means that you only get to save Xykon if you are taking his last Wound, because that is what is "normal" for Wandering Xykon.
Yes. You can target him with anything that targets a Monster that does not specify "except Xykon" or is listed under the "Xykon Special" Monster ability.
No. You may not target him with anything that targets a player unless it also can target a Monster.
No. Durkon can only heal players.
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No. The new movement pattern of moving directly toward the Safe Haven replaces all of the previous movement directions for Xykon, including the one about stopping when he encounters a player.
Yes. Per the rules, "When Xykon ends his movement in a room with one or more players, he Attacks them."
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Yes; when they begin their next turn (after missing one), they start with a fresh set of Wounds.
Fleeing.
No; treat the character as if they were fleeing the dungeon (except don't move them).
No. Wandering Xykon will ignore them as if they were fleeing the dungeon.
No. You would need to rest in order to unflip shticks.
Hadn't thought about that, but sure, that's fair.
Yes and no. It unflips them, meaning that they can be used again, but it does not discard the Screw This! card. So if they become flipped again, they remain flipped. Although there's no reason you can't use Hope of Returning Home to unflip it again, indefinitely.